Event programme - list
Please note, this program is tentative and subject to change without notice.
Please, note that the programme is subject to change, and will be updated continuously up to the congress. If you have any comments or questions directly to the programme, please contact us at abstracts.ephar2021@guarant.cz
All times in the congress programme are in Central European Time – CET (UTC + 1).
Monday, December 06, 2021 09:00 – 10:30
| Virtual Hall 1 | ||
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Opening and Plenary lecture - M. Spedding
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09:00 - 09:05
ID: 634 | Video about the Czech Republic | |
09:05 - 09:10
ID: 635 | M. Kržan - Welcome and congress opening by The EPHAR president | |
09:10 - 09:15
ID: 636 | O. Slanař – Welcome by LOC | |
09:15 - 09:20
ID: 637 | T. Zima - Charles University Rector´s greetings | |
09:20 - 09:25
ID: 638 | I. Storová - Drug regulation agency director´s greetings | |
09:30 - 10:30
ID: 561 | New findings on human evolution, ageing and metabolism allow breakthroughs in ‘impossible diseases’ such as amyotrophic lateral sclerosis (ALS) and insights into COVID-19 | Michael Spedding |
Monday, December 06, 2021 10:50 – 12:20
| Virtual Hall 1 | ||
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S23 Immunopharmacology of endothelial dysfunction
A discussion about all lectures will take place at the end of the session. | ||
10:50 - 11:20
ID: 388 | The β3-adrenergic agonist mirabegron attenuates pulmonary arterial hypertension | Eduardo Oliver |
11:20 - 11:40
ID: 461 | Targeting constitutive androstane receptor decreases endothelial dysfunction | Rebeca Ortega |
11:40 - 12:00
ID: 213 | CSE-H2S pathway is an important target under inflammatory condition in the improvement of endothelial function | Merve Kabasakal |
12:00 - 12:10
ID: 24 | Pathogenic Th17 lymphocytes induces hypertension after high-fructose intake | Inkyeom Kim |
Monday, December 06, 2021 10:50 – 12:20
| Virtual Hall 2 | ||
|
NS 1 WNT signaling as a novel therapeutic target
A discussion about all lectures will take place at the end of the session. | ||
10:50 - 11:10
ID: 585 | WNT-FZD pharmacology:NanoBiT/BRET analysis of WNT-Frizzled binding | Pawel Kozielewicz |
11:10 - 11:30
ID: 597 | WNT signaling as a novel therapeutic target in cardiovascular diseases | W. Matthijs Blankesteijn |
11:30 - 12:00
ID: 644 | Regulation of Wnt signaling in cancer | Michael Boutros |
12:00 - 12:20
ID: 574 | WNT signaling in pulmonary diseases | Reinoud Gosens |
Monday, December 06, 2021 10:50 – 12:20
| Virtual Hall 3 | ||
|
NS 2 Systems Pharmacology – the future directions of drug development
A discussion about all lectures will take place at the end of the session. | ||
10:50 - 11:10
ID: 613 | Network Medicine - From protein-protein to drug-drug interactions | Jörg Menche |
11:10 - 11:30
ID: 614 | Importance of comorbidities and unbiased molecular network analysis to identify molecular targets for cardioprotection. | Peter Ferdinandy |
11:30 - 11:50
ID: 615 | Sytems pharmacology for drug repurposing. | Harald Schmidt |
11:50 - 12:10
ID: 596 | Pharmacovigilance of cardiovascular adverse drug reactions: network analysis | Bence Ágg |
Monday, December 06, 2021 10:50 – 12:20
| Virtual Hall 4 | ||
|
S3 Pharmacogenomics
A discussion about all lectures will take place at the end of the session. | ||
10:50 - 11:10
ID: 153 | Failure to achieve target blood concentration of tacrolimus in transplant patients might be avoided by targeted genotyping: a retrospective study. | Giovanni Pallio |
11:10 - 11:30
ID: 521 | Phenotypic evaluation of the dihydropyrimidine dehydrogenase deficiency by measurement of the dihydrouracil / uracil ratio | Bruno Charlier |
11:30 - 11:45
ID: 517 | Drug-drug interactions-adjusted gene activity score of CYP2D6, CYP2B6 and CYP1A2 refines the prediction of imatinib plasma Ctrough in GIST patients | Chiara Dalle Fratte |
11:45 - 12:00
ID: 518 | An integrated pharmacological counselling approach to improve appropriateness of CDKis prescription: A case series | Rossana Roncato |
12:00 - 12:15
ID: 126 | Pharmacogenetic markers in cardiovascular pharmacology by statins | Galina Mal |
Monday, December 06, 2021 10:50 – 12:20
| Virtual Hall 5 | ||
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NS 16 Molecular basis of highly prevalent diseases. Advances in Pharmacology and Drug delivery
A discussion about all lectures will take place at the end of the session. Juan Tamargo Ester Pagano Manuel Vazquez-Carrera Andrew Owen | ||
10:50 - 11:10
ID: 640 | Advances in heart failure treatment | Juan Tamargo |
11:10 - 11:30
ID: 593 | The potential therapeutic applications of cannabinoids in the control of the inflammatory bowel disease | Ester Pagano |
11:30 - 11:50
ID: 564 | GDF15 is a new player in the activation of AMPK | Manuel Vázquez-Carrera |
Monday, December 06, 2021 12:40 – 13:40
| Virtual Hall 1 | ||
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Plenary Lecture - Prof. Amrita Ahluwalia
| ||
12:40 - 13:40
ID: 610 | Sex differences in cardiovascular inflammation: advantages of the female sex | Amrita AHLUWALIA |
Monday, December 06, 2021 14:40 – 16:10
| Virtual Hall 1 | ||
|
S7 Immunopharmacology
A discussion about all lectures will take place at the end of the session. | ||
14:40 - 15:10
ID: 575 | Immunopharmacological targets for allergy and cancer :are we better off? | Francesca Levi-Schaffer |
15:30 - 15:50
ID: 600 | Biological therapies in the era of immunopharmacology: What do we know about the immunogenicity of monoclonal antibodies? | Ekaterini Tiligada |
15:50 - 16:00
ID: 30 | Study on NLRP3 inflammasome activation inhibited by afatinib | Shujun Xie |
Monday, December 06, 2021 14:40 – 16:10
| Virtual Hall 2 | ||
|
NS 6 New advances and issues in heart failure pharmacology
A discussion about all lectures will take place at the end of the session. | ||
14:40 - 15:00
ID: 639 | Enhancing cardiac PDE activity: a therapeutic strategy in heart failure? | Rodolphe FISCHMEISTER |
15:00 - 15:20
ID: 583 | Cardiac protein phosphatases | Joachim Neumann |
15:20 - 15:40
ID: 586 | Therapeutic potential of cholinesterase inhibitors in heart failure | Anna Paul Hrabovska |
15:40 - 16:00
ID: 594 | Why don't we have better drugs for acute and advanced heart failure? | Zoltán Papp |
Monday, December 06, 2021 14:40 – 16:10
| Virtual Hall 3 | ||
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NS 4 The role of hydrogen sulfide pathways in health and disease (Italian Society)
A discussion about all lectures will take place at the end of the session. Andreas Papapetropoulos Vincenzo Calderone Vincenzo Brancaleone | ||
15:00 - 15:20
ID: 602 | Hydrogen sulfide-based nutraceuticals: preclinical and clinical pharmacology of sulfaceuticals | Vincenzo Calderone |
15:20 - 15:40
ID: 584 | Control of vascular function and inflammation: new insights in the modulation of CSE/H2S pathway | Vincenzo Brancaleone |
Monday, December 06, 2021 14:40 – 16:10
| Virtual Hall 4 | ||
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S10 Advances in diabetes treatment
A discussion about all lectures will take place at the end of the session. | ||
14:40 - 15:10
ID: 576 | Advances in diabetes treatment | Jan Škrha |
15:10 - 15:40
ID: 642 | The non-insulin antidiabetic drugs | Leszek Czupryniak |
15:40 - 15:50
ID: 409 | Baricitinib counteracts metaflammation thus protecting against diet-induced metabolic abnormalities in mice | Debora Collotta |
15:50 - 16:00
ID: 195 | Natural derived chemicals for insulin resistance treatment: isolation and mechanisms of action | Hilal Zaid |
Monday, December 06, 2021 14:40 – 16:10
| Virtual Hall 5 | ||
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S22 GI toxcity
A discussion about all lectures will take place at the end of the session. | ||
14:40 - 15:10
ID: 337 | Assessment of drug induced gastrointestinal toxicity using the organotypic small intestinal tissue model | Jan Markus |
15:10 - 15:40
ID: 408 | Oral bisphenol A exacerbates liver immune-metabolic and mitochondrial dysfunction in adult obese mice: cross-talk between oxidative stress and inflammasome pathway | Claudio Pirozzi |
15:40 - 15:55
ID: 12 | Hepatoprotective mechanism of aristolochia indica and polygonum bistorta against liver failure | Deepak Kumar Mittal |
Tuesday, December 07, 2021 09:00 – 10:00
| Virtual Hall 1 | ||
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Plenary lecture - Harald Enzmann
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09:00 - 10:00
ID: 632 | Innovative Medicines’ Way from Research to Clinical Routine - Regulators’ Contribution | Harald Enzmann |
Tuesday, December 07, 2021 10:20 – 11:50
| Virtual Hall 1 | ||
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S27 Emerging drug targets
A discussion about all lectures will take place at the end of the session. | ||
10:20 - 10:50
ID: 64 | Structural elucidation of ligand binding mechanisms to somatostatin receptors | Csaba Hetényi |
10:50 - 11:20
ID: 81 | Modulators of activity of sigma-1 receptor orthosteric ligands | Edijs Vavers |
11:20 - 11:35
ID: 467 | Identification and characterization of RDM1127, a new kappa opioid receptor (KOR) selective antagonist | Andrea Bedini |
11:35 - 11:50
ID: 40 | Initial results of clinical use of oral thrombolytic | Svetlana Mishenina |
Tuesday, December 07, 2021 10:20 – 11:50
| Virtual Hall 2 | ||
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Therapeutic drug monitoring in clinical practice
A discussion about all lectures will take place at the end of the session. | ||
10:20 - 10:40
ID: 617 | Therapeutic drug monitoring and personalised medicine | Milan Grundmann |
10:40 - 11:00
ID: 493 | Drug interactions of antiepileptic drugs during chronic administration | Blanka Koristkova |
11:00 - 11:20
ID: 497 | Monitoring of valproic acid concentrations at delivery and during lactation | Ivana Kacirova |
11:20 - 11:40
ID: 474 | Therapeutic Monitoring of Sunitinib | Regina Demlova |
Tuesday, December 07, 2021 10:20 – 11:50
| Virtual Hall 3 | ||
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S28 Pharmacological modulation of cardioprotection
| ||
10:20 - 10:40
ID: 386 | Metoprolol exerts a unique myocardial infarct-limiting effect compared to atenolol and propranolol | Agustin Clemente Moragon |
10:40 - 10:55
ID: 113 | IL1-beta and doxorubicin induces cellular senescence in primary adult mouse cardiac fibroblasts | Jenaro Antonio Espitia-Corredor |
10:55 - 11:10
ID: 72 | Decreased long chain acylcarnitine content preserves mitochondrial function in heart during ischemia-reperfusion in TMLHE knockout mice model | Karlis Vilks |
11:10 - 11:25
ID: 13 | ROS y NO are regulated by ovarian hormones in acute and chronic myocardial infarction | Diana Ramirez Hernández |
11:25 - 11:40
ID: 261 | Resolvin D1 has potent anti-inflammatory effects in cardiac fibroblast LPS-treated | Guillermo Díaz-Araya |
Tuesday, December 07, 2021 10:20 – 11:50
| Virtual Hall 4 | ||
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NS 10 Treatment of migraine, mechanisms, pharmacology, challenges
A discussion about all lectures will take place at the end of the session.
| ||
10:20 - 11:00
ID: 647 | Pathophysiology and current treatment of Migraine | Mark Braschinsky |
11:00 - 11:20
ID: 619 | CGRP as target for migraine treatment - Clinical data (history, CGRP AB and CGRP small molecules) | Simone Sacco |
11:20 - 11:40
ID: 620 | Novel antimigraine targets other than CGRP (PACAP, 5-HT1F, etc.) | Antoinette Maassen van den Brink |
Tuesday, December 07, 2021 10:20 – 11:50
| Virtual Hall 5 | ||
|
S26 Pharmacological insigths in obesity
A discussion about all lectures will take place at the end of the session. | ||
10:20 - 10:40
ID: 469 | The bioactive N-palmitoylethanolamine protects against obesity promoting metabolic reprogramming of adipocytes: evidence for PPARalpha involvement | Chiara Annunziata |
10:40 - 11:00
ID: 169 | A Citrus bergamia juice extract exerts protective effect against hepatic steatosis and fibrosis induced by HFD-consumption in C57BL/6J mice | Giovanni Enrico Lombardo |
11:00 - 11:15
ID: 3 | Drug-induced obesity alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats | Feng Xu |
11:15 - 11:30
ID: 140 | The multi-faceted effects of palmitoylethanolamide in high-fat diet-induced obese mice: focus on metabolic impairment and mood disorders | Adriano Lama |
11:30 - 11:45
ID: 191 | Effects of pioglitazone on perivascular adipose tissue (PVAT) in type-2 diabetic rats | Erkan Civelek |
Tuesday, December 07, 2021 12:10 – 13:25
| Virtual Hall 1 | ||
|
EPHAR Lecture 1+2
A discussion about all lectures will take place at the end of the session. | ||
12:10 - 12:40
ID: 568 | Endothelial deCYStiny: Cysteinolysis and endothelial fate decisions | Sofia Iris Bibli |
12:40 - 13:10
ID: 605 | Gut vibes in Parkinson's disease: the microbiota-gut-brain axis | Paula Perez Pardo |
Tuesday, December 07, 2021 14:25 – 15:55
| Virtual Hall 1 | ||
|
S14 Recent advances in pharmacological strategies to control respiratory diseases: from animal models to human therapy
A discussion about all lectures will take place at the end of the session. | ||
14:25 - 14:45
ID: 559 | Role of Angiotensin II Type 2 Receptor in Chronic Obstructive Pulmonary Disease | W.S. Fred Wong |
14:45 - 15:05
ID: 268 | Cholinergic Anti-inflammatory Pathway Activation By Vagus Nerve Stimulation Induces Anti-Inflammatory Effects In Allergic Asthma | Caroline Sevoz-Couche |
15:05 - 15:30
ID: 558 | Phosphodiesterase (PDE) Inhibitors as novel drugs for the treatment of respiratory diseases | Clive Page |
15:30 - 15:55
ID: 339 | Genomics guided drug target discovery in asthma | Reinoud Gosens |
Tuesday, December 07, 2021 14:25 – 15:55
| Virtual Hall 2 | ||
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NS 18 Academic Clinical Trials and Research in Europe
A discussion about all lectures will take place at the end of the session. | ||
14:25 - 14:40
ID: 622 | ECRIN-ERIC – infrastructure supporting academic clinical research | Christine Kubiak |
14:40 - 15:00
ID: 624 | Clinical trials in Europe – where we are now and what we plan for future? | Jacques Demotes |
15:00 - 15:15
ID: 591 | ECRIN-ERIC as a part of EOSC Consortium | Steve Canham |
15:15 - 15:30
ID: 625 | CZECRIN research projects and portfolio of services | Regina Demlova |
15:30 - 15:50
ID: 641 | GMP development of somatic cell therapies | Lenka Zdražilová Dubská |
Tuesday, December 07, 2021 14:25 – 15:55
| Virtual Hall 3 | ||
|
NS 11 Paradigm shifts in cardiac safety testing of drugs
A discussion about all lectures will take place at the end of the session.
| ||
14:25 - 14:45
ID: 618 | Hidden cardiotoxicity: paradigm change in cardiac safety testing in ischemic and comorbid conditions | Peter Ferdinandy |
14:45 - 15:05
ID: 645 | Transgenic rabbit models of long QT syndrome for testing proarrhythmic adverse effects | Istvan Baczko |
15:05 - 15:25
ID: 606 | Phosphoinositide 3-kinase gamma is a master regulator of doxorubicin-induced metabolic rewiring of cardiomyocytes. | Emilio Hirsch |
15:25 - 15:45
ID: 598 | Heart failure and cancer: cardiotoxic drugs in cancer patients | Carlo Gabriele Tocchetti |
Tuesday, December 07, 2021 14:25 – 15:55
| Virtual Hall 4 | ||
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NS 7 Ion channel structure: implications for function, pharmacology and disease
A discussion about all lectures will take place at the end of the session. 14:25 - 14:55
| ||
14:55 - 15:25
ID: 299 | Cav1.3 Ca2+ channelopathies: from hypertension to autism | Nadine J. Ortner |
15:25 - 15:40
ID: 526 | Fatty acids as activators of the cardiac Kv7.1 channel | Sara Liin |
15:40 - 15:55
ID: 410 | Restoration of trafficking-defective ClC-1 chloride channel mutants causing myotonia congenita using pharmacological chaperones | Concetta Altamura |
Tuesday, December 07, 2021 14:25 – 15:55
| Virtual Hall 5 | ||
|
S25 New approaches to inflammatory disorders
A discussion about all lectures will take place at the end of the session. | ||
14:45 - 15:05
ID: 523 | Changes in small bowel inhibitory neurotransmission in a mouse model of experimental inflammation | Sofia Faggin |
15:05 - 15:20
ID: 366 | Repurposing pharmacological agents: amitriptyline, naloxone and thalidomide prevent innate immune responses in rheumatic diseases | María Guillán-Fresco |
15:20 - 15:35
ID: 112 | Studying the anti-inflammatory and analgesic effect of Transient Receptor Potential Canonical 5 (TRPC5) agonist (-)-Englerin-A | Joao de Sousa Valente |
15:35 - 15:50
ID: 320 | Toll-Like receptor 4 signaling influences small intestine neuromotor function in a mouse model of dextran sulfate sodium-induced colitis | Silvia Cerantola |
Tuesday, December 07, 2021 16:15 – 17:45
| Virtual Hall 1 | ||
|
NS 9 Ca2+ channels as new therapeutic targets
A discussion about all lectures will take place at the end of the session. | ||
16:15 - 16:45
ID: 579 | A gene therapeutic approach for Timothy syndrome | Ivy Dick |
16:45 - 17:15
ID: 595 | Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for Parkinson’s Disease | Kathy Steece-Collier |
17:15 - 17:45
ID: 183 | Gating defects in CACNA1I T-type calcium channel containing heterozygous mutations identified in patients with intellectual disability and epilepsy. | Yousra El Ghaleb |
Tuesday, December 07, 2021 16:15 – 17:45
| Virtual Hall 2 | ||
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NS 12 Astrocytes in the CNS pharmacology
A discussion about all lectures will take place at the end of the session. | ||
16:15 - 16:35
ID: 361 | Principles of astrogliopathology | Alexei Verkhratsky |
16:35 - 16:55
ID: 287 | Adrenergic Regulation of Astrocytes in Health and Disease | Robert ZOREC |
16:55 - 17:15
ID: 331 | Amyloid precursor protein, Alzheimer’s disease and astrocytes | Gorazd Bernard Stokin |
17:15 - 17:35
ID: 301 | Astrocytes – pharmacological targets or medicinal product | Metoda Lipnik-Stangelj |
Tuesday, December 07, 2021 16:15 – 17:45
| Virtual Hall 3 | ||
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NS 17 Novel targets for the inhibition of neuro-immune-vascular interactions in the CNS and the periphery
| ||
16:15 - 16:35
ID: 375 | Mechanisms of microglia-neuron-vascular interactions and implications for brain disease | Adam Denes |
16:35 - 16:55
ID: 646 | Blocking the interleukin-1 pathway for the inhibition of Complex Regional Pain Syndrome | Andreas Goebel |
16:55 - 17:20
ID: 407 | Antibody activation of sensory neurons - exploring novel pain mechanisms in rheumatoid arthritis | Alex Bersellini Farinotti |
17:20 - 17:45
ID: 378 | Small molecule somatostatin 4 receptor agonists are novel analgesic and antidepressant drug candidates | Zsuzsanna Helyes |
Tuesday, December 07, 2021 16:15 – 17:45
| Virtual Hall 4 | ||
|
S9 IFAPP Professionalism in Medicines Development
A discussion about all lectures will take place at the end of the session. | ||
16:15 - 16:35
ID: 626 | Global needs for education in Medicines Development | Domenico Criscuolo |
16:40 - 17:00
ID: 582 | The evolving ethical framework for developing advanced therapies | Sandor Dr. Kerpel-Fronius |
17:00 - 17:20
ID: 578 | Fostering professional identity in medicines development: the Global Fellow initiative | Honorio Silva |
17:20 - 17:40
ID: 627 | Cooperation between academy and industry in fostering entrustable professional activities | Peter Stonier |
Wednesday, December 08, 2021 09:00 – 10:00
| Virtual Hall 1 | ||
|
Plenary lecture - Achilleas Gravanis
Brain-on-chip platforms in therapeutics of neurodegeneration | ||
09:00 - 10:00
ID: 567 | Human brain on chip platforms in therapeutics of neurodegeneration | Achilleas GRAVANIS |
Wednesday, December 08, 2021 10:20 – 11:50
| Virtual Hall 1 | ||
|
S24 Advances in modulation of neurodegenerative disorders
A discussion about all lectures will take place at the end of the session. | ||
10:20 - 10:40
ID: 433 | Absence of tissue transglutaminase reduces amyloid-beta pathology in APP23 mice | Micha Wilhelmus |
10:40 - 11:00
ID: 334 | Impact of postnatal celastrol administration on cortical redox and inflammatory states of early ketamine-treated adult mice | Stefania Schiavone |
11:00 - 11:15
ID: 252 | Early treatment with co-ultramicronized palmitoylethanolamide and luteolin prevents Aβ-induced neuroinflammation in rats | Marta Valenza |
11:15 - 11:30
ID: 103 | Inhibition of BDNF receptor (TrkB-FL) cleavage as a therapeutic strategy for Alzheimer’s disease | Maria J. Diógenes |
11:30 - 11:45
ID: 291 | Anti-miR-155-5p slows down the progression of retinitis pigmentosa in mice rd10 models | Beatrice Polini |
Wednesday, December 08, 2021 10:20 – 11:50
| Virtual Hall 2 | ||
|
S19 Novel approaches in cancer treatment
A discussion about all lectures will take place at the end of the session. | ||
10:20 - 10:50
ID: 563 | Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis? | Jan Brábek |
10:50 - 11:20
ID: 628 | Immunotargeting of cancer and escape mechanisms identified by live-cell microscopy | Peter Friedl |
11:20 - 11:30
ID: 275 | Marine meroterpenoids as potential anticancer agents in colon and lung cancer | Hanaa Zbakh |
11:30 - 11:40
ID: 318 | Tumor suppressor role of hsa-microRNA-193a-3p and -5p in cutaneous melanoma | Sara Carpi |
11:40 - 11:50
ID: 437 | Extracellular CD73 in cancer as a predictive biomarker in cancer immunotherapy | Silvana Morello |
Wednesday, December 08, 2021 10:20 – 11:50
| Virtual Hall 3 | ||
|
NS 15 Advanced drug delivery
| ||
10:20 - 11:50
ID: 373 | Application of yeast glucan particles as immunoactive drug delivery systems | Frantisek Stepanek |
10:50 - 11:20
ID: 650 | Advances in lipids based drug delivery | Anette Müllertz |
11:20 - 11:30
ID: 571 | Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate - manufacturing of the formulation | Ondrej Rychecky |
11:30 - 11:40
ID: 566 | Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate – in vitro performance | Tereza Krejčí |
11:40 - 11:50
ID: 572 | Development of novel Oil marbles formulation of abiraterone acetate for bioavailability enhancement – in vivo preclinical testing | Pavel Ryšánek |
Wednesday, December 08, 2021 10:20 – 11:50
| Virtual Hall 4 | ||
|
NS 14 The future of pharmacology
A discussion about all lectures will take place at the end of the session. David Webb
| ||
10:20 - 10:40
ID: 570 | IUPHAR and governance changes | Ingolf Cascorbi |
10:40 - 11:00
ID: 629 | The present and future of clinical pharmacology | David Webb |
11:00 - 11:20
ID: 560 | Scientific futures for pharmacology | Michael Spedding |
11:20 - 11:40
ID: 603 | From receptor databases to health challenges | Steve Alexander |
Wednesday, December 08, 2021 10:20 – 11:50
Wednesday, December 08, 2021 12:10 – 13:10
| Virtual Hall 1 | ||
|
Plenary lecture - Zdravko Lackovic
| ||
12:10 - 13:10
ID: 609 | Paradigm shift in botulinum toxin research: from peripheral neuromuscur blockade to axonal transport with antinociceptive and other new central functions | Zdravko Lackovic |
Wednesday, December 08, 2021 14:10 – 15:40
| Virtual Hall 1 | ||
|
NS 20 Pharmacogenomics – A Promising Tool in Precision Medicine
A discussion about all lectures will take place at the end of the session. | ||
14:10 - 14:25
ID: 255 | Pre-emptive pharmacogenetic testing across Europe: The U-PGx project | Vita Dolžan |
14:25 - 14:40
ID: 228 | Pharmacogenetics of pain management in patients after breast cancer surgery | Katja Goričar |
14:40 - 14:55
ID: 200 | The challenges of pharmacogenomic testing | Lana Ganoci |
14:55 - 15:10
ID: 468 | DPYD polymorphism c.496A>G and risk of severe adverse drug reactions in cancer patients treated with fluoropyrimidine-based protocols | Lana Ganoci |
15:10 - 15:25
ID: 180 | ABCG2 gene variants as important predictors of drug-drug-gene interactions | Nada Bozina |
Wednesday, December 08, 2021 14:10 – 15:40
| Virtual Hall 2 | ||
|
NS 22 Regulation of drug metabolism
A discussion about all lectures will take place at the end of the session. | ||
14:10 - 14:35
ID: 592 | Pregnane X receptor in drug-induced hypercholesterolemia | Jukka Hakkola |
14:35 - 15:00
ID: 581 | Pregnane X receptor (PXR) mediated regulation of main cytochrome P450 enzymes in 3D spheroids of human hepatocytes | Petr Pávek |
15:00 - 15:25
ID: 577 | Gut microbiome and drug metabolism | Lenka Jourová |
Wednesday, December 08, 2021 14:10 – 15:40
| Virtual Hall 3 | ||
|
NS 13 Molecular and cellular determinants of pain
Speakers: Michaela Kress | ||
14:10 - 14:30
ID: 604 | Interleukin-6 signal transducer as hub regulator of nociception | Michaela Kress |
14:30 - 14:50
ID: 580 | Modulation of the pain pathway by phytocannabinoids | Avi Priel |
14:50 - 15:10
ID: 569 | The gain changer: inflammation-induced plasticity of action potential initiation in peripheral nociceptive neurons | Alex Binshtok |
15:10 - 15:30
ID: 573 | Optopharmacological Modulation of Corneal Cold Thermoreceptor Activity and Cold-evoked Blink Reflex | Victor Meseguer |
Wednesday, December 08, 2021 14:10 – 15:40
| Virtual Hall 4 | ||
|
NS 8 Hot, cold and spicy: TRP channels as drug targets
| ||
14:10 - 14:30
ID: 367 | TRP channels, cardiovascular regulation and the cold. | Susan Brain |
14:30 - 14:50
ID: 369 | TRP channels in gastrointestinal diseases | Daniel Keszthelyi |
14:50 - 15:10
ID: 364 | Transient receptor potential vanilloid-1 (TRPV1) channel antagonists without influencing thermoregulation | Andras Garami |
15:10 - 15:25
ID: 590 | Targeting TRPA1 in peripheral and CNS inflammation | Erika Pinter |
Wednesday, December 08, 2021 16:00 – 17:30
| Virtual Hall 1 | ||
|
Clinical Pharmacy Methodology, Education and Practical Application: comparison of three countries (Czech Republic, Great Britain, USA)
Symposium organized by Czech Professional Society of Clinical Pharmacy A discussion about all lectures will take place at the end of the session. | ||
16:00 - 16:25
ID: 607 | Clinical Pharmacy Practice in the U.S.:The Role of Education and Credentialing in the Development and Expansion of Clinical Pharmacy Services | Marketa Marvanova |
16:25 - 16:50
ID: 599 | The work of a clinical pharmacist in the UK – my experience | Karolína Russ |
16:50 - 17:15
ID: 589 | Clinical pharmacy methodology, organization, education and practice in the Czech Republic | Jan Hartinger |
Wednesday, December 08, 2021 16:00 – 17:30
| Virtual Hall 2 | ||
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NS 19 Pharmacology competences for antimicrobial stewardship
A discussion about all lectures will take place at the end of the session.
| ||
16:00 - 16:25
ID: 630 | Clinical pharmacology consultations to improve rational use of antimicrobials: steps towards stewardship program | Simona Stankeviciute |
16:25 - 16:40
ID: 631 | ATB stewardship during covid times | Kristina Nadrah |
16:40 - 17:05
ID: 588 | Case study in nefrology. How clinical pharmacologist could contribute improving appropriate use of antimicrobials | Romaldas Maciulaitis |
17:05 - 17:20
ID: 531 | Therapeutic drug monitoring of vancomycin - exploring of dosing estimates | Martin Šíma |
Wednesday, December 08, 2021 16:00 – 17:30
| Virtual Hall 3 | ||
|
S5 Pharmacology of oxidative stress
| ||
16:00 - 16:25
ID: 332 | The importance of modulation of oxidative stress in cancer therapy | Luciano Saso |
16:25 - 16:50
ID: 601 | Oxidative stress estimation in pharmacological studies | Jelena Kotur-Stevuljević |
16:50 - 17:00
ID: 290 | Targeting the master neuronal epigenetic regulator REST as new pharmacological strategy for intervention in Amyotrophic Lateral Sclerosis. | Natascia Guida |
17:00 - 17:10
ID: 413 | Effects of lifelong omega-3 deficient diet in β amyloid-treated rats: role of redox system | Maria Bove |
17:10 - 17:20
ID: 494 | Edaravone attenuates disease severity of experimental auto-immune encephalomyelitis and increases gene expression of Nrf2 and HO-1 | Hatice Kübra Öztürk |
Wednesday, December 08, 2021 16:00 – 17:30
| Virtual Hall 4 | ||
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Recent advances in cannabinoid pharmacology: From Bench to Bedside
A discussion about all lectures will take place at the end of the session. | ||
16:00 - 16:20
ID: 648 | Cannabidiol (CBD) as human medicine – phase 2 trials for US Food and Drug Administration approval | Mark Rosenfeld |
16:20 - 16:40
ID: 612 | Therapeutic approaches of Cannabinoids in Neurological and Neurodegenerative Disorders | Mark S. Kindy |
17:00 - 17:20
ID: 611 | Improving the Intestinal Absorption, Efficiency and Selectivity of Cannabidiol (CBD): Importance to the Treatment of Disease States | Pavel Gershkovich |
Wednesday, December 08, 2021 17:30 – 18:00
| Virtual Hall 1 | ||
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Closing Ceremony
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