Event programme - list

Please note, this program is tentative and subject to change without notice.

Please, note that the programme is subject to change, and will be updated continuously up to the congress. If you have any comments or questions directly to the programme, please contact us at abstracts.ephar2021@guarant.cz

All times in the congress programme are in Central European Time – CET (UTC + 1).

Monday, December 06, 2021 09:00 – 10:30

Virtual Hall 1
Opening and Plenary lecture - M. Spedding

Chair: Mojca Kržan, Ondrej Slanař

09:00 - 09:05
ID: 634
Video about the Czech Republic
09:05 - 09:10
ID: 635
M. Kržan - Welcome and congress opening by The EPHAR president
09:10 - 09:15
ID: 636
O. Slanař – Welcome by LOC
09:15 - 09:20
ID: 637
T. Zima - Charles University Rector´s greetings
09:20 - 09:25
ID: 638
I. Storová - Drug regulation agency director´s greetings
09:30 - 10:30
ID: 561
New findings on human evolution, ageing and metabolism allow breakthroughs in ‘impossible diseases’ such as amyotrophic lateral sclerosis (ALS) and insights into COVID-19
Michael Spedding

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 1
S23 Immunopharmacology of endothelial dysfunction

Chair: Eduardo Oliver, Eva Kmoníčková

A discussion about all lectures will take place at the end of the session. 

10:50 - 11:20
ID: 388
The β3-adrenergic agonist mirabegron attenuates pulmonary arterial hypertension
Eduardo Oliver
11:20 - 11:40
ID: 461
Targeting constitutive androstane receptor decreases endothelial dysfunction
Rebeca Ortega
11:40 - 12:00
ID: 213
CSE-H2S pathway is an important target under inflammatory condition in the improvement of endothelial function
Merve Kabasakal
12:00 - 12:10
ID: 24
Pathogenic Th17 lymphocytes induces hypertension after high-fructose intake
Inkyeom Kim

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 2
NS 1 WNT signaling as a novel therapeutic target

Chair: WM Blankesteijn

A discussion about all lectures will take place at the end of the session.

10:50 - 11:10
ID: 585
WNT-FZD pharmacology:NanoBiT/BRET analysis of WNT-Frizzled binding
Pawel Kozielewicz
11:10 - 11:30
ID: 597
WNT signaling as a novel therapeutic target in cardiovascular diseases
W. Matthijs Blankesteijn
11:30 - 12:00
ID: 644
Regulation of Wnt signaling in cancer
Michael Boutros
12:00 - 12:20
ID: 574
WNT signaling in pulmonary diseases
Reinoud Gosens

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 3
NS 2 Systems Pharmacology – the future directions of drug development

Chair: Péter Ferdinandy, Harald Schmidt

A discussion about all lectures will take place at the end of the session. 

10:50 - 11:10
ID: 613
Network Medicine - From protein-protein to drug-drug interactions
Jörg Menche
11:10 - 11:30
ID: 614
Importance of comorbidities and unbiased molecular network analysis to identify molecular targets for cardioprotection.
Peter Ferdinandy
11:30 - 11:50
ID: 615
Sytems pharmacology for drug repurposing.
Harald Schmidt
11:50 - 12:10
ID: 596
Pharmacovigilance of cardiovascular adverse drug reactions: network analysis
Bence Ágg

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 5
NS 16 Molecular basis of highly prevalent diseases. Advances in Pharmacology and Drug delivery

Chair: Juan Tamargo, Manuel Vazquez-Carrera

Symposium organizer: Maria J. Sanz, Valentin Cena

A discussion about all lectures will take place at the end of the session. 

Juan Tamargo
Advances in heart failure treatment

Ester Pagano
The potential therapeutic applications of cannabinoids in the control of the inflammatory bowel disease

Manuel Vazquez-Carrera
GDF15 is a new player in the activation of AMPK

Andrew Owen
Nanotechnology-based drug delivery: new solutions to improve pharmacokinetic performance

10:50 - 11:10
ID: 640
Advances in heart failure treatment
Juan Tamargo
11:10 - 11:30
ID: 593
The potential therapeutic applications of cannabinoids in the control of the inflammatory bowel disease
Ester Pagano
11:30 - 11:50
ID: 564
GDF15 is a new player in the activation of AMPK
Manuel Vázquez-Carrera

Monday, December 06, 2021 12:40 – 13:40

Virtual Hall 1
Plenary Lecture - Prof. Amrita Ahluwalia

Chair: Giuseppe Cirino

12:40 - 13:40
ID: 610
Sex differences in cardiovascular inflammation: advantages of the female sex
Amrita AHLUWALIA

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 1
S7 Immunopharmacology

Chair: Francesca Levi-Schaffer, Ekaterini Tiligada

A discussion about all lectures will take place at the end of the session. 

14:40 - 15:10
ID: 575
Immunopharmacological targets for allergy and cancer :are we better off?
Francesca Levi-Schaffer
15:30 - 15:50
ID: 600
Biological therapies in the era of immunopharmacology: What do we know about the immunogenicity of monoclonal antibodies?
Ekaterini Tiligada
15:50 - 16:00
ID: 30
Study on NLRP3 inflammasome activation inhibited by afatinib
Shujun Xie

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 2
NS 6 New advances and issues in heart failure pharmacology

Chair: Martin Štěrba, Ján Klimas

A discussion about all lectures will take place at the end of the session. 

14:40 - 15:00
ID: 639
Enhancing cardiac PDE activity: a therapeutic strategy in heart failure?
Rodolphe FISCHMEISTER
15:00 - 15:20
ID: 583
Cardiac protein phosphatases
Joachim Neumann
15:20 - 15:40
ID: 586
Therapeutic potential of cholinesterase inhibitors in heart failure
Anna Paul Hrabovska
15:40 - 16:00
ID: 594
Why don't we have better drugs for acute and advanced heart failure?
Zoltán Papp

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 3
NS 4 The role of hydrogen sulfide pathways in health and disease (Italian Society)

Chair: Giuseppe Cirino, Andreas Papapetropoulos

A discussion about all lectures will take place at the end of the session. 

Andreas Papapetropoulos
Adipocyte biology and hydrogen sulfide: implications for obesity

Vincenzo Calderone
Hydrogen sulfide-based nutraceuticals: preclinical and clinical pharmacology of sulfaceuticals

Vincenzo Brancaleone
Control of vascular function and inflammation: new insights in the modulation of CSE/H2S pathway

15:00 - 15:20
ID: 602
Hydrogen sulfide-based nutraceuticals: preclinical and clinical pharmacology of sulfaceuticals
Vincenzo Calderone
15:20 - 15:40
ID: 584
Control of vascular function and inflammation: new insights in the modulation of CSE/H2S pathway
Vincenzo Brancaleone

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 4
S10 Advances in diabetes treatment

Chair: Jan Škrha, Leszek Czupryniak

A discussion about all lectures will take place at the end of the session. 

14:40 - 15:10
ID: 576
Advances in diabetes treatment
Jan Škrha
15:10 - 15:40
ID: 642
The non-insulin antidiabetic drugs
Leszek Czupryniak
15:40 - 15:50
ID: 409
Baricitinib counteracts metaflammation thus protecting against diet-induced metabolic abnormalities in mice
Debora Collotta
15:50 - 16:00
ID: 195
Natural derived chemicals for insulin resistance treatment: isolation and mechanisms of action
Hilal Zaid

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 5
S22 GI toxcity

Chair: Marek Puskar, Claudio Pirozzi

A discussion about all lectures will take place at the end of the session. 

14:40 - 15:10
ID: 337
Assessment of drug induced gastrointestinal toxicity using the organotypic small intestinal tissue model
Jan Markus
15:10 - 15:40
ID: 408
Oral bisphenol A exacerbates liver immune-metabolic and mitochondrial dysfunction in adult obese mice: cross-talk between oxidative stress and inflammasome pathway
Claudio Pirozzi
15:40 - 15:55
ID: 12
Hepatoprotective mechanism of aristolochia indica and polygonum bistorta against liver failure
Deepak Kumar Mittal

Tuesday, December 07, 2021 09:00 – 10:00

Virtual Hall 1
Plenary lecture - Harald Enzmann

Chair: Ondřej Slanař

09:00 - 10:00
ID: 632
Innovative Medicines’ Way from Research to Clinical Routine - Regulators’ Contribution
Harald Enzmann

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 1
S27 Emerging drug targets

Chair: Csaba Hetényi, Baiba Svalbe

A discussion about all lectures will take place at the end of the session. 

10:20 - 10:50
ID: 64
Structural elucidation of ligand binding mechanisms to somatostatin receptors
Csaba Hetényi
10:50 - 11:20
ID: 81
Modulators of activity of sigma-1 receptor orthosteric ligands
Edijs Vavers
11:20 - 11:35
ID: 467
Identification and characterization of RDM1127, a new kappa opioid receptor (KOR) selective antagonist
Andrea Bedini
11:35 - 11:50
ID: 40
Initial results of clinical use of oral thrombolytic
Svetlana Mishenina

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 2
Therapeutic drug monitoring in clinical practice

Chair: Milan Grundmann

A discussion about all lectures will take place at the end of the session. 

10:20 - 10:40
ID: 617
Therapeutic drug monitoring and personalised medicine
Milan Grundmann
10:40 - 11:00
ID: 493
Drug interactions of antiepileptic drugs during chronic administration
Blanka Koristkova
11:00 - 11:20
ID: 497
Monitoring of valproic acid concentrations at delivery and during lactation
Ivana Kacirova
11:20 - 11:40
ID: 474
Therapeutic Monitoring of Sunitinib
Regina Demlova

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 3
S28 Pharmacological modulation of cardioprotection

Chair: Nikolina Canova, Jiří Slíva

10:20 - 10:40
ID: 386
Metoprolol exerts a unique myocardial infarct-limiting effect compared to atenolol and propranolol
Agustin Clemente Moragon
10:40 - 10:55
ID: 113
IL1-beta and doxorubicin induces cellular senescence in primary adult mouse cardiac fibroblasts
Jenaro Antonio Espitia-Corredor
10:55 - 11:10
ID: 72
Decreased long chain acylcarnitine content preserves mitochondrial function in heart during ischemia-reperfusion in TMLHE knockout mice model
Karlis Vilks
11:10 - 11:25
ID: 13
ROS y NO are regulated by ovarian hormones in acute and chronic myocardial infarction
Diana Ramirez Hernández
11:25 - 11:40
ID: 261
Resolvin D1 has potent anti-inflammatory effects in cardiac fibroblast LPS-treated
Guillermo Díaz-Araya

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 4
NS 10 Treatment of migraine, mechanisms, pharmacology, challenges

Chair: Antoinette Maassen van den Brink

A discussion about all lectures will take place at the end of the session. 

 

 

10:20 - 11:00
ID: 647
Pathophysiology and current treatment of Migraine
Mark Braschinsky
11:00 - 11:20
ID: 619
CGRP as target for migraine treatment - Clinical data (history, CGRP AB and CGRP small molecules)
Simone Sacco
11:20 - 11:40
ID: 620
Novel antimigraine targets other than CGRP (PACAP, 5-HT1F, etc.)
Antoinette Maassen van den Brink

Tuesday, December 07, 2021 12:10 – 13:25

Virtual Hall 1
EPHAR Lecture 1+2

Chair: Mojca Kržan, Robin Hiley

A discussion about all lectures will take place at the end of the session. 

12:10 - 12:40
ID: 568
Endothelial deCYStiny: Cysteinolysis and endothelial fate decisions
Sofia Iris Bibli
12:40 - 13:10
ID: 605
Gut vibes in Parkinson's disease: the microbiota-gut-brain axis
Paula Perez Pardo

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 1
S14 Recent advances in pharmacological strategies to control respiratory diseases: from animal models to human therapy

Chair: Caroline Sevoz-Couche, Wai-Shiu Wong

A discussion about all lectures will take place at the end of the session. 

14:25 - 14:45
ID: 559
Role of Angiotensin II Type 2 Receptor in Chronic Obstructive Pulmonary Disease
W.S. Fred Wong
14:45 - 15:05
ID: 268
Cholinergic Anti-inflammatory Pathway Activation By Vagus Nerve Stimulation Induces Anti-Inflammatory Effects In Allergic Asthma
Caroline Sevoz-Couche
15:05 - 15:30
ID: 558
Phosphodiesterase (PDE) Inhibitors as novel drugs for the treatment of respiratory diseases
Clive Page
15:30 - 15:55
ID: 339
Genomics guided drug target discovery in asthma
Reinoud Gosens

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 2
NS 18 Academic Clinical Trials and Research in Europe

Chair: Christine Kubiak, Regina Demlova

A discussion about all lectures will take place at the end of the session. 

14:25 - 14:40
ID: 622
ECRIN-ERIC – infrastructure supporting academic clinical research
Christine Kubiak
14:40 - 15:00
ID: 624
Clinical trials in Europe – where we are now and what we plan for future?
Jacques Demotes
15:00 - 15:15
ID: 591
ECRIN-ERIC as a part of EOSC Consortium
Steve Canham
15:15 - 15:30
ID: 625
CZECRIN research projects and portfolio of services
Regina Demlova
15:30 - 15:50
ID: 641
GMP development of somatic cell therapies
Lenka Zdražilová Dubská

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 3
NS 11 Paradigm shifts in cardiac safety testing of drugs

Chair: Péter Ferdinandy, Emilo Hirsch

Symposium organizer: Péter Ferdinandy

A discussion about all lectures will take place at the end of the session. 

 

14:25 - 14:45
ID: 618
Hidden cardiotoxicity: paradigm change in cardiac safety testing in ischemic and comorbid conditions
Peter Ferdinandy
14:45 - 15:05
ID: 645
Transgenic rabbit models of long QT syndrome for testing proarrhythmic adverse effects
Istvan Baczko
15:05 - 15:25
ID: 606
Phosphoinositide 3-kinase gamma is a master regulator of doxorubicin-induced metabolic rewiring of cardiomyocytes.
Emilio Hirsch
15:25 - 15:45
ID: 598
Heart failure and cancer: cardiotoxic drugs in cancer patients
Carlo Gabriele Tocchetti

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 4
NS 7 Ion channel structure: implications for function, pharmacology and disease

Chair: Ivy Dick

Symposium organizer: Joerg Striessnig

A discussion about all lectures will take place at the end of the session. 

14:25 - 14:55
Jianping Wu
Molecular Basis for Ca2+ -Antagonist Modulation of L-type Voltage-Gated Ca2+ Channels

 

14:55 - 15:25
ID: 299
Cav1.3 Ca2+ channelopathies: from hypertension to autism
Nadine J. Ortner
15:25 - 15:40
ID: 526
Fatty acids as activators of the cardiac Kv7.1 channel
Sara Liin
15:40 - 15:55
ID: 410
Restoration of trafficking-defective ClC-1 chloride channel mutants causing myotonia congenita using pharmacological chaperones
Concetta Altamura

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 5
S25 New approaches to inflammatory disorders

Chair: Debora Collotta, Danica Michalickova

A discussion about all lectures will take place at the end of the session. 

14:45 - 15:05
ID: 523
Changes in small bowel inhibitory neurotransmission in a mouse model of experimental inflammation
Sofia Faggin
15:05 - 15:20
ID: 366
Repurposing pharmacological agents: amitriptyline, naloxone and thalidomide prevent innate immune responses in rheumatic diseases
María Guillán-Fresco
15:20 - 15:35
ID: 112
Studying the anti-inflammatory and analgesic effect of Transient Receptor Potential Canonical 5 (TRPC5) agonist (-)-Englerin-A
Joao de Sousa Valente
15:35 - 15:50
ID: 320
Toll-Like receptor 4 signaling influences small intestine neuromotor function in a mouse model of dextran sulfate sodium-induced colitis
Silvia Cerantola

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 1
NS 9 Ca2+ channels as new therapeutic targets

Chair: Nadine Ortner

A discussion about all lectures will take place at the end of the session. 

16:15 - 16:45
ID: 579
A gene therapeutic approach for Timothy syndrome
Ivy Dick
16:45 - 17:15
ID: 595
Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for Parkinson’s Disease
Kathy Steece-Collier
17:15 - 17:45
ID: 183
Gating defects in CACNA1I T-type calcium channel containing heterozygous mutations identified in patients with intellectual disability and epilepsy.
Yousra El Ghaleb

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 2
NS 12 Astrocytes in the CNS pharmacology

Chair: Damijana Mojca Juric

A discussion about all lectures will take place at the end of the session. 

16:15 - 16:35
ID: 361
Principles of astrogliopathology
Alexei Verkhratsky
16:35 - 16:55
ID: 287
Adrenergic Regulation of Astrocytes in Health and Disease
Robert ZOREC
16:55 - 17:15
ID: 331
Amyloid precursor protein, Alzheimer’s disease and astrocytes
Gorazd Bernard Stokin
17:15 - 17:35
ID: 301
Astrocytes – pharmacological targets or medicinal product
Metoda Lipnik-Stangelj

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 3
NS 17 Novel targets for the inhibition of neuro-immune-vascular interactions in the CNS and the periphery

Chair: Zsuzsanna Helyes, Andreas Goebel

16:15 - 16:35
ID: 375
Mechanisms of microglia-neuron-vascular interactions and implications for brain disease
Adam Denes
16:35 - 16:55
ID: 646
Blocking the interleukin-1 pathway for the inhibition of Complex Regional Pain Syndrome
Andreas Goebel
16:55 - 17:20
ID: 407
Antibody activation of sensory neurons - exploring novel pain mechanisms in rheumatoid arthritis
Alex Bersellini Farinotti
17:20 - 17:45
ID: 378
Small molecule somatostatin 4 receptor agonists are novel analgesic and antidepressant drug candidates
Zsuzsanna Helyes

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 4
S9 IFAPP Professionalism in Medicines Development

Chair: Domenico Criscuolo, Sandor Kerpel-Fronius

Symposium organizer: Sandor Kerpel-Fronius

A discussion about all lectures will take place at the end of the session. 

16:15 - 16:35
ID: 626
Global needs for education in Medicines Development
Domenico Criscuolo
16:40 - 17:00
ID: 582
The evolving ethical framework for developing advanced therapies
Sandor Dr. Kerpel-Fronius
17:00 - 17:20
ID: 578
Fostering professional identity in medicines development: the Global Fellow initiative
Honorio Silva
17:20 - 17:40
ID: 627
Cooperation between academy and industry in fostering entrustable professional activities
Peter Stonier

Wednesday, December 08, 2021 09:00 – 10:00

Virtual Hall 1
Plenary lecture - Achilleas Gravanis

Chair: Eva Kmoníčková

Brain-on-chip platforms in therapeutics of neurodegeneration

09:00 - 10:00
ID: 567
Human brain on chip platforms in therapeutics of neurodegeneration
Achilleas GRAVANIS

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 1
S24 Advances in modulation of neurodegenerative disorders

Chair: Micha Wilhelmus, Stefania Schiavone

A discussion about all lectures will take place at the end of the session. 

10:20 - 10:40
ID: 433
Absence of tissue transglutaminase reduces amyloid-beta pathology in APP23 mice
Micha Wilhelmus
10:40 - 11:00
ID: 334
Impact of postnatal celastrol administration on cortical redox and inflammatory states of early ketamine-treated adult mice
Stefania Schiavone
11:00 - 11:15
ID: 252
Early treatment with co-ultramicronized palmitoylethanolamide and luteolin prevents Aβ-induced neuroinflammation in rats
Marta Valenza
11:15 - 11:30
ID: 103
Inhibition of BDNF receptor (TrkB-FL) cleavage as a therapeutic strategy for Alzheimer’s disease
Maria J. Diógenes
11:30 - 11:45
ID: 291
Anti-miR-155-5p slows down the progression of retinitis pigmentosa in mice rd10 models
Beatrice Polini

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 2
S19 Novel approaches in cancer treatment

Chair: Jan Brábek

A discussion about all lectures will take place at the end of the session. 

10:20 - 10:50
ID: 563
Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?
Jan Brábek
10:50 - 11:20
ID: 628
Immunotargeting of cancer and escape mechanisms identified by live-cell microscopy
Peter Friedl
11:20 - 11:30
ID: 275
Marine meroterpenoids as potential anticancer agents in colon and lung cancer
Hanaa Zbakh
11:30 - 11:40
ID: 318
Tumor suppressor role of hsa-microRNA-193a-3p and -5p in cutaneous melanoma
Sara Carpi
11:40 - 11:50
ID: 437
Extracellular CD73 in cancer as a predictive biomarker in cancer immunotherapy
Silvana Morello

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 3
NS 15 Advanced drug delivery

Chair: František Štěpánek

Symposium organizer: Ondřej Dammer

10:20 - 11:50
ID: 373
Application of yeast glucan particles as immunoactive drug delivery systems
Frantisek Stepanek
10:50 - 11:20
ID: 650
Advances in lipids based drug delivery
Anette Müllertz
11:20 - 11:30
ID: 571
Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate - manufacturing of the formulation
Ondrej Rychecky
11:30 - 11:40
ID: 566
Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate – in vitro performance
Tereza Krejčí
11:40 - 11:50
ID: 572
Development of novel Oil marbles formulation of abiraterone acetate for bioavailability enhancement – in vivo preclinical testing
Pavel Ryšánek

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 4
NS 14 The future of pharmacology

Chair: Ondřej Slanař, Ingolf Cascorbi

Symposium organizer: Michael Spedding

A discussion about all lectures will take place at the end of the session. 

David Webb
The present and future of clinical pharmacology

 

10:20 - 10:40
ID: 570
IUPHAR and governance changes
Ingolf Cascorbi
10:40 - 11:00
ID: 629
The present and future of clinical pharmacology
David Webb
11:00 - 11:20
ID: 560
Scientific futures for pharmacology
Michael Spedding
11:20 - 11:40
ID: 603
From receptor databases to health challenges
Steve Alexander

Wednesday, December 08, 2021 12:10 – 13:10

Virtual Hall 1
Plenary lecture - Zdravko Lackovic

Chair: Mojca Kržan

12:10 - 13:10
ID: 609
Paradigm shift in botulinum toxin research: from peripheral neuromuscur blockade to axonal transport with antinociceptive and other new central functions
Zdravko Lackovic

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 1
NS 20 Pharmacogenomics – A Promising Tool in Precision Medicine

Chair: Nada Božina

A discussion about all lectures will take place at the end of the session. 

14:10 - 14:25
ID: 255
Pre-emptive pharmacogenetic testing across Europe: The U-PGx project
Vita Dolžan
14:25 - 14:40
ID: 228
Pharmacogenetics of pain management in patients after breast cancer surgery
Katja Goričar
14:40 - 14:55
ID: 200
The challenges of pharmacogenomic testing
Lana Ganoci
14:55 - 15:10
ID: 468
DPYD polymorphism c.496A>G and risk of severe adverse drug reactions in cancer patients treated with fluoropyrimidine-based protocols
Lana Ganoci
15:10 - 15:25
ID: 180
ABCG2 gene variants as important predictors of drug-drug-gene interactions
Nada Bozina

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 2
NS 22 Regulation of drug metabolism

Chair: Petr Pávek

A discussion about all lectures will take place at the end of the session. 

14:10 - 14:35
ID: 592
Pregnane X receptor in drug-induced hypercholesterolemia
Jukka Hakkola
14:35 - 15:00
ID: 581
Pregnane X receptor (PXR) mediated regulation of main cytochrome P450 enzymes in 3D spheroids of human hepatocytes
Petr Pávek
15:00 - 15:25
ID: 577
Gut microbiome and drug metabolism
Lenka Jourová

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 3
NS 13 Molecular and cellular determinants of pain

Chair: Alex Binshtok, Avi Priel

Symposium organizer: Alex Binshtok

Speakers:

Michaela Kress
Avi Priel
Victor Meseguer
Alex Binshtok

14:10 - 14:30
ID: 604
Interleukin-6 signal transducer as hub regulator of nociception
Michaela Kress
14:30 - 14:50
ID: 580
Modulation of the pain pathway by phytocannabinoids
Avi Priel
14:50 - 15:10
ID: 569
The gain changer: inflammation-induced plasticity of action potential initiation in peripheral nociceptive neurons
Alex Binshtok
15:10 - 15:30
ID: 573
Optopharmacological Modulation of Corneal Cold Thermoreceptor Activity and Cold-evoked Blink Reflex
Victor Meseguer

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 4
NS 8 Hot, cold and spicy: TRP channels as drug targets

Chair: Zsuzsanna Helyes, Susan D. Brain

14:10 - 14:30
ID: 367
TRP channels, cardiovascular regulation and the cold.
Susan Brain
14:30 - 14:50
ID: 369
TRP channels in gastrointestinal diseases
Daniel Keszthelyi
14:50 - 15:10
ID: 364
Transient receptor potential vanilloid-1 (TRPV1) channel antagonists without influencing thermoregulation
Andras Garami
15:10 - 15:25
ID: 590
Targeting TRPA1 in peripheral and CNS inflammation
Erika Pinter

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 1
Clinical Pharmacy Methodology, Education and Practical Application: comparison of three countries (Czech Republic, Great Britain, USA)

Chair: Marketa Marvanova, Jan Hartinger

Symposium organized by Czech Professional Society of Clinical Pharmacy

A discussion about all lectures will take place at the end of the session. 

16:00 - 16:25
ID: 607
Clinical Pharmacy Practice in the U.S.:The Role of Education and Credentialing in the Development and Expansion of Clinical Pharmacy Services
Marketa Marvanova
16:25 - 16:50
ID: 599
The work of a clinical pharmacist in the UK – my experience
Karolína Russ
16:50 - 17:15
ID: 589
Clinical pharmacy methodology, organization, education and practice in the Czech Republic
Jan Hartinger

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 2
NS 19 Pharmacology competences for antimicrobial stewardship

Chair: Romaldas Maciulaitis, Kristina Nadrah

A discussion about all lectures will take place at the end of the session. 

 

16:00 - 16:25
ID: 630
Clinical pharmacology consultations to improve rational use of antimicrobials: steps towards stewardship program
Simona Stankeviciute
16:25 - 16:40
ID: 631
ATB stewardship during covid times
Kristina Nadrah
16:40 - 17:05
ID: 588
Case study in nefrology. How clinical pharmacologist could contribute improving appropriate use of antimicrobials
Romaldas Maciulaitis
17:05 - 17:20
ID: 531
Therapeutic drug monitoring of vancomycin - exploring of dosing estimates
Martin Šíma

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 3
S5 Pharmacology of oxidative stress

Chair: Luciano Saso, Jelena Kotur-Stevuljević

16:00 - 16:25
ID: 332
The importance of modulation of oxidative stress in cancer therapy
Luciano Saso
16:25 - 16:50
ID: 601
Oxidative stress estimation in pharmacological studies
Jelena Kotur-Stevuljević
16:50 - 17:00
ID: 290
Targeting the master neuronal epigenetic regulator REST as new pharmacological strategy for intervention in Amyotrophic Lateral Sclerosis.
Natascia Guida
17:00 - 17:10
ID: 413
Effects of lifelong omega-3 deficient diet in β amyloid-treated rats: role of redox system
Maria Bove
17:10 - 17:20
ID: 494
Edaravone attenuates disease severity of experimental auto-immune encephalomyelitis and increases gene expression of Nrf2 and HO-1
Hatice Kübra Öztürk

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 4
Recent advances in cannabinoid pharmacology: From Bench to Bedside

Chair: Mark J. Rosenfeld, Mark S. Kindy

A discussion about all lectures will take place at the end of the session. 

16:00 - 16:20
ID: 648
Cannabidiol (CBD) as human medicine – phase 2 trials for US Food and Drug Administration approval
Mark Rosenfeld
16:20 - 16:40
ID: 612
Therapeutic approaches of Cannabinoids in Neurological and Neurodegenerative Disorders
Mark S. Kindy
17:00 - 17:20
ID: 611
Improving the Intestinal Absorption, Efficiency and Selectivity of Cannabidiol (CBD): Importance to the Treatment of Disease States
Pavel Gershkovich

Wednesday, December 08, 2021 17:30 – 18:00

Virtual Hall 1
Closing Ceremony

Chair: Mojca Kržan, Ondrej Slanar, Andreas Papapetropoulos