Event programme - list

Please note, this program is tentative and subject to change without notice.

Please, note that the programme is subject to change, and will be updated continuously up to the congress. If you have any comments or questions directly to the programme, please contact us at abstracts.ephar2021@guarant.cz

All times in the congress programme are in Central European Time – CET (UTC + 1).

Monday, December 06, 2021 09:00 – 10:30

Virtual Hall 1
Opening and Plenary lecture - M. Spedding

Chair: Mojca Kržan, Eva Kmonickova

New findings on human evolution, ageing and metabolism allow breakthroughs in ‘impossible diseases’ such as amyotrophic lateral sclerosis (ALS) and insights into COVID-19

09:30 - 10:30
ID: 561
New findings on human evolution, ageing and metabolism allow breakthroughs in ‘impossible diseases’ such as amyotrophic lateral sclerosis (ALS) and insights into COVID-19

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 1
S23 Immunopharmacology of endothelial dysfunction

Chair: Eduardo Oliver

10:50 - 11:20
ID: 388
The β3-adrenergic agonist mirabegron attenuates pulmonary arterial hypertension
Eduardo Oliver
11:20 - 11:40
ID: 461
Targeting constitutive androstane receptor decreases endothelial dysfunction
Rebeca Ortega
11:40 - 12:00
ID: 213
CSE-H2S pathway is an important target under inflammatory condition in the improvement of endothelial function
Merve Kabasakal
12:00 - 12:10
ID: 24
Pathogenic Th17 lymphocytes induces hypertension after high-fructose intake
Inkyeom Kim

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 2
NS 1 WNT signaling as a novel therapeutic target

Chair: WM Blankesteijn

Pawel Kozielewicz
TBA

Matthijs Blankesteijn
WNT signaling as a novel therapeutic target in cardiovascular diseases

Reinout Gosens
WNT signaling in pulmonary diseases

M. Boutros
WNT signaling in cancer

10:50 - 11:10
ID: 574
WNT signaling in pulmonary diseases
Reinoud Gosens

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 3
NS 2 Systems Pharmacology – the future directions of drug development

Chair: Péter Ferdinandy, Harald Schmidt

Jörg Menche, Wien, Austria
Network Medicine - From protein-protein to drug-drug interactions

Péter Ferdinandy, Budapest, Hungary
Importance of comorbidities and unbiased molecular network analysis to identify molecular targets for cardioprotection.

Harald HHW Schmidt, Maastricht, The Netherlands
Sytems pharmacology for drug repurposing.

Bence Ágg, Budapest, Hungary
Pharmacovigilance of cardiovascular adverse drug reactions: network analysis

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 4
S3 Pharmacogenomics

Chair: Vita Dolžan, Ondrej Slanar

10:50 - 11:10
ID: 153
Failure to achieve target blood concentration of tacrolimus in transplant patients might be avoided by targeted genotyping: a retrospective study.
Giovanni Pallio
11:10 - 11:30
ID: 521
Phenotypic evaluation of the dihydropyrimidine dehydrogenase deficiency by measurement of the dihydrouracil / uracil ratio
Bruno Charlier
11:30 - 11:45
ID: 517
Drug-drug interactions-adjusted gene activity score of CYP2D6, CYP2B6 and CYP1A2 refines the prediction of imatinib plasma Ctrough in GIST patients
Chiara Dalle Fratte
11:45 - 12:00
ID: 518
An integrated pharmacological counselling approach to improve appropriateness of CDKis prescription: A case series
Rossana Roncato
12:00 - 12:15
ID: 126
Pharmacogenetic markers in cardiovascular pharmacology by statins
Galina Mal

Monday, December 06, 2021 10:50 – 12:20

Virtual Hall 5
NS 16 Molecular basis of highly prevalent diseases. Advances in Pharmacology and Drug delivery

Chair: Juan Tamargo, Manuel Vazquez-Carrera

Symposium organizer: Maria J. Sanz, Valentin Cena

Juan Tamargo
Advances in heart failure treatment

Ester Pagano
The potential therapeutic applications of cannabinoids in the control of the inflammatory bowel disease

Manuel Vazquez-Carrera
GDF15 is a new player in the activation of AMPK

Andrew Owen
Nanotechnology-based drug delivery: new solutions to improve pharmacokinetic performance

11:35 - 11:55
ID: 564
GDF15 is a new player in the activation of AMPK
Manuel Vázquez-Carrera

Monday, December 06, 2021 12:40 – 13:40

Virtual Hall 1
Plenary Lecture - Prof. Amrita Ahluwalia

Chair: Giuseppe Cirino

Sex differences in cardiovascular inflammation: advantages of the female sex

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 1
S7 Immunopharmacology

Chair: Francesca Levi-Schaffer, Ekaterini Tiligada

Francesca Levi-Schaffer
Immunopharmacological targets for allergy and cancer :are we better off?

Ekaterini Tiligada 
Biological therapies in the era of immunopharmacology: What do we know about the immunogenicity of monoclonal antibodies?

14:40 - 15:10
ID: 575
Immunopharmacological targets for allergy and cancer :are we better off?
Francesca Levi-Schaffer
15:50 - 16:00
ID: 30
Study on NLRP3 inflammasome activation inhibited by afatinib
Shujun Xie

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 2
NS 6 New advances and issues in heart failure pharmacology

Chair: Martin Štěrba, Ján Klimas

R. Fischmeister
Enhancing cardiac PDE activity: a therapeutic strategy in heart failure?

J. Neumann
Role of phosphatases in heart failure

A. Paul Hrabovska
Therapeutic potential of cholinesterase inhibitors in heart failure

Z. Papp
Why don't we have better drugs for acute and advanced heart failure?

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 3
NS 4 The role of hydrogen sulfide pathways in health and disease (Italian Society)

Chair: Giuseppe Cirino, Andreas Papapetropoulos

Andreas Papapetropoulos
Adipocyte biology and hydrogen sulfide: implications for obesity

Vincenzo Calderone
Hydrogen sulfide-based nutraceuticals: preclinical and clinical pharmacology of sulfaceuticals

Vincenzo Brancaleone
Control of vascular function and inflammation: new insights in the modulation of CSE/H2S pathway

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 4
S10 Advances in diabetes treatment

Chair: Jan Škrha, Leszek Czupryniak

14:40 - 15:10
J Skrha: Advances in diabetes treatment
15:10 - 15:40
Leszek Czupryniak: The non-insulin antidiabetic drugs
15:40 - 15:50
Debora Collotta: Baricitinib counteracts metaflammation thus protecting against diet-induced metabolic abnormalities in mice
15:50 - 16:00
Hilal Zaid: Natural derived chemicals for insulin resistance treatment: isolation and mechanisms of action
Discussion

14:40 - 15:00
ID: 576
Advances in diabetes treatment
Jan Škrha
15:20 - 15:40
ID: 409
Baricitinib counteracts metaflammation thus protecting against diet-induced metabolic abnormalities in mice
Debora Collotta
15:40 - 16:00
ID: 195
Natural derived chemicals for insulin resistance treatment: isolation and mechanisms of action
Hilal Zaid

Monday, December 06, 2021 14:40 – 16:10

Virtual Hall 5
S22 GI toxcity

Chair: Marek Puskar, Claudio Pirozzi

14:40 - 15:10
ID: 337
Assessment of drug induced gastrointestinal toxicity using the organotypic small intestinal tissue model
Jan Markus
15:10 - 15:40
ID: 408
Oral bisphenol A exacerbates liver immune-metabolic and mitochondrial dysfunction in adult obese mice: cross-talk between oxidative stress and inflammasome pathway
Claudio Pirozzi
15:40 - 15:55
ID: 12
Hepatoprotective mechanism of aristolochia indica and polygonum bistorta against liver failure
Deepak Kumar Mittal

Tuesday, December 07, 2021 09:00 – 10:00

Virtual Hall 1
Plenary lecture - Harald Enzmann

Chair: Ondřej Slanař

Innovative medicines’ way from research to clinical routine - regulators’ contribution

 

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 1
S27 Emerging drug targets

Chair: Csaba Hetényi, Baiba Svalbe

10:20 - 10:50
ID: 64
Structural elucidation of ligand binding mechanisms to somatostatin receptors
Csaba Hetényi
10:50 - 11:20
ID: 81
Modulators of activity of sigma-1 receptor orthosteric ligands
Edijs Vavers
11:20 - 11:35
ID: 467
Identification and characterization of RDM1127, a new kappa opioid receptor (KOR) selective antagonist
Andrea Bedini
11:35 - 11:50
ID: 40
Initial results of clinical use of oral thrombolytic
Svetlana Mishenina

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 2
Therapeutic drug monitoring in clinical practice

Chair: Milan Grundmann

Grundmann Milan
Therapeutic drug monitoring and personalised medicine

Koristkova Blanka
Drug interactions of antiepileptic drugs during chronic administration

Kacirova Ivana
Monitoring of valproic acid concentrations at delivery and during lactation

Demlova Regina
Therapeutic monitoring of sunitinib

10:40 - 11:00
ID: 493
Drug interactions of antiepileptic drugs during chronic administration
Blanka Koristkova
11:00 - 11:20
ID: 497
Monitoring of valproic acid concentrations at delivery and during lactation
Ivana Kacirova
11:20 - 11:40
ID: 474
Therapeutic Monitoring of Sunitinib
Regina Demlova

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 3
S28 Pharmacological modulation of cardioprotection

Chair: Nikolina Canova, Jiří Slíva

 

 

10:20 - 10:40
ID: 386
Metoprolol exerts a unique myocardial infarct-limiting effect compared to atenolol and propranolol
Agustin Clemente Moragon
10:40 - 10:55
ID: 113
IL1-beta and doxorubicin induces cellular senescence in primary adult mouse cardiac fibroblasts
Jenaro Antonio Espitia-Corredor
10:55 - 11:10
ID: 72
Decreased long chain acylcarnitine content preserves mitochondrial function in heart during ischemia-reperfusion in TMLHE knockout mice model
Karlis Vilks
11:10 - 11:25
ID: 13
ROS y NO are regulated by ovarian hormones in acute and chronic myocardial infarction
Diana Ramirez Hernández
11:25 - 11:40
ID: 261
Resolvin D1 has potent anti-inflammatory effects in cardiac fibroblast LPS-treated
Guillermo Díaz-Araya

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 4
NS 10 Treatment of migraine, mechanisms, pharmacology, challenges

Chair: Antoinette Maassen van den Brink

Mark Braschnisky
Pathophysiology and current treatment of Migraine – Mark Braschinsky

Debby Hay
CGRP as target for migraine treatment - Basic science

Simone Sacco
CGRP as target for migraine treatment - Clinical data (history, CGRP AB and CGRP small molecules)

Antoinette Maassen van den Brink
Novel antimigraine targets other than CGRP (PACAP, 5-HT1F, etc.)

Tuesday, December 07, 2021 10:20 – 11:50

Virtual Hall 5
S26 Pharmacological insigths in obesity

Chair: Chiara Annunziata, Stanislav Mičuda

10:20 - 10:40
ID: 469
The bioactive N-palmitoylethanolamine protects against obesity promoting metabolic reprogramming of adipocytes: evidence for PPARalpha involvement
Chiara Annunziata
10:40 - 11:00
ID: 169
A Citrus bergamia juice extract exerts protective effect against hepatic steatosis and fibrosis induced by HFD-consumption in C57BL/6J mice
Giovanni Enrico Lombardo
11:00 - 11:15
ID: 3
Drug-induced obesity alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats
Feng Xu
11:15 - 11:30
ID: 140
The multi-faceted effects of palmitoylethanolamide in high-fat diet-induced obese mice: focus on metabolic impairment and mood disorders
Adriano Lama
11:30 - 11:45
ID: 191
Effects of pioglitazone on perivascular adipose tissue (PVAT) in type-2 diabetic rats
Erkan Civelek

Tuesday, December 07, 2021 12:10 – 13:25

Virtual Hall 1
EPHAR Lecture 1+2

Chair: Mojca Kržan

12:40 - 13:10
Paula Perez Pardo
Gut vibes in Parkinson's disease: the microbiota-gut-brain axis

12:10 - 12:40
ID: 568
Endothelial deCYStiny: Cysteinolysis and endothelial fate decisions
Sofia Iris Bibli

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 1
S14 Recent advances in pharmacological strategies to control respiratory diseases: from animal models to human therapy

Chair: Caroline Sevoz-Couche, Wai-Shiu Wong

Speakers:

Wai-Shiu WONG
Caroline SEVOZ-COUCHE
Clive PAGE
Reinoud GOSENS

14:25 - 14:45
ID: 559
Role of Angiotensin II Type 2 Receptor in Chronic Obstructive Pulmonary Disease
W.S. Fred Wong
14:45 - 15:05
ID: 268
Cholinergic Anti-inflammatory Pathway Activation By Vagus Nerve Stimulation Induces Anti-Inflammatory Effects In Allergic Asthma
Caroline Sevoz-Couche
15:05 - 15:30
ID: 558
Phosphodiesterase (PDE) Inhibitors as novel drugs for the treatment of respiratory diseases
Clive Page
15:30 - 15:55
ID: 339
Genomics guided drug target discovery in asthma
Reinoud Gosens

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 2
NS 18 Academic Clinical Trials and Research in Europe

Chair: Christine Kubiak, Regina Demlova

14:25 - 14:40 Christine Kubiak
ECRIN-ERIC – infrastructure supporting academic clinical research

14:40 - 15:00 Jacques Demotes
Clinical trials in Europe – where we are now and what we plan for future? 

15:00 - 15:15 Steve Canham
ECRIN-ERIC as a part of EOSC consortium

15:15 - 15:30 Regina Demlova
CZECRIN research projects and portfolio of services

15:30 - 15:50 Lenka Zdrazilova Dubska
GMP development of somatic cell therapies

- 15:50 - 15:55 discussion

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 3
NS 11 Paradigm shifts in cardiac safety testing of drugs

Chair: Péter Ferdinandy, Emilo Hirsch

Symposium organizer: Péter Ferdinandy

Emilio Hirsh
Mechanisms of cardiotoxity: what we learnt form doxorubicin?

Péter Ferdinandy
Hidden cardiotoxicity: paradigm change in cardiac safety testing in ischemic and comorbid conditions

István Baczkó
Transgenic rabbit models of long QT syndrome for testing proarrhythmic adverse effects

Carlo Gabriele Tocchetti
Heart failure and cancer: cardiotoxic drugs in cancer patients

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 4
NS 7 Ion channel structure: implications for function, pharmacology and disease

Chair: Ivy Dick

Symposium organizer: Joerg Striessnig

14:25 - 14:55
Jianping Wu
Molecular Basis for Ca2+ -Antagonist Modulation of L-type Voltage-Gated Ca2+ Channels

 

14:55 - 15:25
ID: 299
Cav1.3 Ca2+ channelopathies: from hypertension to autism
Nadine J. Ortner
15:25 - 15:40
ID: 526
Fatty acids as activators of the cardiac Kv7.1 channel
Sara Liin
15:40 - 15:55
ID: 410
Restoration of trafficking-defective ClC-1 chloride channel mutants causing myotonia congenita using pharmacological chaperones
Concetta Altamura

Tuesday, December 07, 2021 14:25 – 15:55

Virtual Hall 5
S25 New approaches to inflammatory disorders

Chair: Debora Collotta, Danica Michalickova

14:45 - 15:05
ID: 523
Changes in small bowel inhibitory neurotransmission in a mouse model of experimental inflammation
Sofia Faggin
15:05 - 15:20
ID: 366
Repurposing pharmacological agents: amitriptyline, naloxone and thalidomide prevent innate immune responses in rheumatic diseases
María Guillán-Fresco
15:20 - 15:35
ID: 112
Studying the anti-inflammatory and analgesic effect of Transient Receptor Potential Canonical 5 (TRPC5) agonist (-)-Englerin-A
Joao de Sousa Valente
15:35 - 15:50
ID: 320
Toll-Like receptor 4 signaling influences small intestine neuromotor function in a mouse model of dextran sulfate sodium-induced colitis
Silvia Cerantola

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 1
NS 9 Ca2+ channels as new therapeutic targets

Chair: Nadine Ortner

16:15 – 16:45
Ivy Dick
A gene therapeutic approach for Timothy Syndrome

16:45 – 17:15
Kathy Steece-Collier
Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for Parkinson’s Disease

17:15 – 17:45
Yousra el Ghaleb
Gating changes of CACNA1I T-type calcium channel de novo mutations in patients with intellectual disability and epilepsy

17:15 - 17:45
ID: 183
Gating defects in CACNA1I T-type calcium channel containing heterozygous mutations identified in patients with intellectual disability and epilepsy.
Yousra El Ghaleb

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 2
NS12 Astrocytes in the CNS pharmacology

Chair: Damijana Mojca Juric

Alexei Verkhratsky
Principles of astrogliopathology 

Robert Zorec
Adrenergic regulation of astrocytes in health and disease

Gorazd B Stokin
Amyloid precursor protein, Alzheimer’s disease and astrocytes

Metoda Lipnik-Štangelj
Astrocytes – pharmacological targets or medicinal product 

16:15 - 16:35
ID: 361
Principles of astrogliopathology
Alexei Verkhratsky
16:35 - 16:55
ID: 287
Adrenergic Regulation of Astrocytes in Health and Disease
Robert ZOREC
16:55 - 17:15
ID: 331
Amyloid precursor protein, Alzheimer’s disease and astrocytes
Gorazd Bernard Stokin
17:15 - 17:35
ID: 301
Astrocytes – pharmacological targets or medicinal product
Metoda Lipnik-Stangelj

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 3
NS 17 Novel targets for the inhibition of neuro-immune-vascular interactions in the CNS and the periphery

Chair: Zsuzsanna Helyes, Andreas Goebel

Adam Denes
Mechanisms of microglia-neurone interactions

Andreas Goebel
Blocking the interleukin-1 pathway for the inhibition of Complex Regional Pain Syndrome

Alex Bersellini Farinotti
Antibody activation of sensory neurons - exploring novel pain mechanisms in rheumatoid arthritis

Zsuzsanna Helyes
Small molecule somatostatin 4 receptor agonists are novel anti-inflammatory, analgesic and antidepressant drug candidates

16:15 - 16:35
ID: 375
Mechanisms of microglia-neuron-vascular interactions and implications for brain disease
Adam Denes
16:50 - 17:10
ID: 407
Antibody activation of sensory neurons - exploring novel pain mechanisms in rheumatoid arthritis
Alex Bersellini Farinotti

Tuesday, December 07, 2021 16:15 – 17:45

Virtual Hall 4
S9 IFAPP Professionalism in Medicines Development

Chair: Domenico Criscuolo

Symposium organizer: Sandor Kerpel-Fronius

D. Criscuolo
Global needs for education in Medicines Development

S. Kerpel-Fronius
The evolving ethical framework for developing advanced therapies

H. Silva
Fostering Professional Identity/The IFAPP Global Fellow Initiative

P. Stonier
Cooperation between academy and industry in fostering entrustable professional activities

17:00 - 17:20
ID: 578
Fostering professional identity in medicines development: the Global Fellow initiative
Honorio Silva

Tuesday, December 07, 2021 18:05 – 19:05

Virtual Hall 1
EPHAR council meeting

Wednesday, December 08, 2021 09:00 – 10:00

Virtual Hall 1
Plenary lecture - Achilleas Gravanis

Brain-on-chip platforms in therapeutics of neurodegeneration

09:00 - 10:00
ID: 567
Human brain on chip platforms in therapeutics of neurodegeneration
Achilleas GRAVANIS

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 1
S24 Advances in modulation of neurodegenerative disorders

Chair: Micha Wilhelmus, Stefania Schiavone

10:20 - 10:40
ID: 433
Absence of tissue transglutaminase reduces amyloid-beta pathology in APP23 mice
Micha Wilhelmus
10:40 - 11:00
ID: 334
Impact of postnatal celastrol administration on cortical redox and inflammatory states of early ketamine-treated adult mice
Stefania Schiavone
11:00 - 11:15
ID: 252
Early treatment with co-ultramicronized palmitoylethanolamide and luteolin prevents Aβ-induced neuroinflammation in rats
Marta Valenza
11:15 - 11:30
ID: 103
Inhibition of BDNF receptor (TrkB-FL) cleavage as a therapeutic strategy for Alzheimer’s disease
Maria J. Diógenes
11:30 - 11:45
ID: 291
Anti-miR-155-5p slows down the progression of retinitis pigmentosa in mice rd10 models
Beatrice Polini

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 2
S19 Novel approaches in cancer treatment

Chair: Jan Brábek

Jan Brábek
Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

Peter Friedl
Targeting integrin regulation and MMPs - old suspects revisited

 

 

10:45 - 11:10
ID: 563
Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?
Jan Brábek
11:10 - 11:20
ID: 275
Marine meroterpenoids as potential anticancer agents in colon and lung cancer
Hanaa Zbakh
11:20 - 11:30
ID: 318
Tumor suppressor role of hsa-microRNA-193a-3p and -5p in cutaneous melanoma
Sara Carpi
11:30 - 11:40
ID: 437
Extracellular CD73 in cancer as a predictive biomarker in cancer immunotherapy
Silvana Morello

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 3
NS 15 Advanced drug delivery

Chair: František Štěpánek

Symposium organizer: Ondřej Dammer

Speakers:

Anette Mullertz

František Štěpánek

 

10:20 - 10:40
ID: 373
Application of yeast glucan particles as immunoactive drug delivery systems
Frantisek Stepanek
11:20 - 11:30
ID: 571
Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate - manufacturing of the formulation
Ondrej Rychecky
11:30 - 11:40
ID: 566
Development of novel bioavailability enhancing Oil marbles formulation of abiraterone acetate – in vitro performance
Tereza Krejčí
11:40 - 11:50
ID: 572
Development of novel Oil marbles formulation of abiraterone acetate for bioavailability enhancement – in vivo preclinical testing
Pavel Ryšánek

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 4
NS 14 The future of pharmacology

Chair: Ondřej Slanař, Ingolf Cascorbi

Symposium organizer: Michael Spedding

Ingolf Cascorbi
IUPHAR and governance changes

David Webb
The present and future of clinical pharmacology

Michael Spedding
Scientific futures for pharmacology

Steve Alexander
From receptor databases to healt

10:20 - 10:40
ID: 570
IUPHAR and governance changes
Ingolf Cascorbi
11:00 - 11:20
ID: 560
Scientific futures for pharmacology
Michael Spedding

Wednesday, December 08, 2021 10:20 – 11:50

Virtual Hall 5
S21 Immunopharmacology of cardiovascular system

Chair: Maria Jesus Sanz, Maria Giovanna Lupo

10:20 - 10:40
ID: 92
Cardiovascular benefits of PCSK9 blockade: a new promising therapeutic approach to control systemic inflammation in patients with familial hypercholesterolemia
Maria Jesus Sanz
10:40 - 11:00
ID: 485
Anti-PCSK9 monoclonal antibodies administration produces an increase in PCSK9 plasma levels: investigation of the basic molecular mechanisms.
Maria Giovanna Lupo
11:00 - 11:20
ID: 507
Evaluation of serum and urinary lipoxins and FPR2/ALX receptor expression in human acute heart failure, cardiogenic shock and septic shock
Patricia Pereira-Terra
11:20 - 11:30
ID: 245
Comparison of endothelial activation profiles in critically ill patients with cardiogenic shock, septic shock and severe COVID-19
Carolina Silva-Pereira
11:30 - 11:40
ID: 256
Inflammatory and resolution of inflammation responses in critically ill patients with cardiogenic shock, septic shock and severe COVID-19
Marta Reina-Couto

Wednesday, December 08, 2021 12:10 – 13:10

Virtual Hall 1
Plenary lecture - Zdravko Lackovic

Chair: Mojca Kržan

Paradigm shift in botulinum toxin research: from peripheral neuromuscular blockade to axonal transport with antinociceptive and other central effects

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 1
NS 20 Pharmacogenomics – A Promising Tool in Precision Medicine

Chair: Nada Božina

Vita Dolžan
Pre-emptive pharmacogenetic testing across Europe: The U-PGx project

Katja Goričar
Pharmacogenetics of pain management in patients after breast cancer surgery

Lana Ganoci
Challenges of pharmacogenomic testing

Nada Božina
ABCG2 gene variants as important predictors of drug-drug-gene interactions

14:10 - 14:25
ID: 255
Pre-emptive pharmacogenetic testing across Europe: The U-PGx project
Vita Dolžan
14:25 - 14:40
ID: 228
Pharmacogenetics of pain management in patients after breast cancer surgery
Katja Goričar
14:40 - 14:55
ID: 200
The challenges of pharmacogenomic testing
Lana Ganoci
14:55 - 15:10
ID: 468
DPYD polymorphism c.496A>G and risk of severe adverse drug reactions in cancer patients treated with fluoropyrimidine-based protocols
Lana Ganoci
15:10 - 15:25
ID: 180
ABCG2 gene variants as important predictors of drug-drug-gene interactions
Nada Bozina

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 2
NS 22 Regulation of drug metabolism

Chair: Petr Pávek

Jukka Hakkola
TBA

Petr Pavek, PhD
Pregnane X receptor (PXR)-mediated regulation of main cytochrome P450 enzymes in 3D spheroids of human hepatocytes

Chiara Dalle Fratte
Drug-drug interactions-adjusted gene activity score of CYP2D6, CYP2B6 and CYP1A2 refines the prediction of imatinib plasma Ctrough in GIST patients

Lenka a Jourová
Gut microbiome and Drug metabolism

15:10 - 15:30
ID: 577
Gut microbiome and drug metabolism
Lenka Jourová

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 3
NS 13 Molecular and cellular determinants of pain

Chair: Alex Binshtok, Avi Priel

Symposium organizer: Alex Binshtok

Speakers:

Michaela Kress
Avi Priel
Victor Meseguer
Alex Binshtok

14:50 - 15:10
ID: 569
The gain changer: inflammation-induced plasticity of action potential initiation in peripheral nociceptive neurons
Alex Binshtok
15:10 - 15:30
ID: 573
Optopharmacological Modulation of Corneal Cold Thermoreceptor Activity and Cold-evoked Blink Reflex
Victor Meseguer

Wednesday, December 08, 2021 14:10 – 15:40

Virtual Hall 4
NS 8 Hot, cold and spicy: TRP channels as drug targets

Chair: Zsuzsanna Helyes, Susan D. Brain

Susan D Brain
TRP channels regulate cardiovascular functions

Daniel Keszthelyi
TRP channels in gastrointenstinal diseases

Andras Garami
TRPV1 antagonists without influencing thermoregulation.

Erika Pinter
Targeting TRPA1 in peripheral and CNS inflammation

14:10 - 14:30
ID: 367
TRP channels, cardiovascular regulation and the cold.
Susan Brain
14:30 - 14:50
ID: 369
TRP channels in gastrointestinal diseases
Daniel Keszthelyi
14:50 - 15:10
ID: 364
Transient receptor potential vanilloid-1 (TRPV1) channel antagonists without influencing thermoregulation
Andras Garami
15:10 - 15:30
ID: 371
Targeting TRPA1 in peripheral and CNS inflammation
Erika Pinter

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 1
Clinical Pharmacy Methodology, Education and Practical Application: comparison of three countries (Czech Republic, Great Britain, USA)

Chair: Marketa Marvanova, Jan Hartinger

symposium organized by Czech Professional Society of Clinical Pharmacy

16:00 - 16:25
Marketa Marvanova
Clinical Pharmacy Practice in the United States: The Role of Education, Training and Credentialing in the Development and Expansion of Clinical Pharmacy Services

16:25 - 16:50
Karolína Russ
The work of a clinical pharmacist in the UK

16:50 - 17:15
Jan Miroslav Hartinger, Jana Gregorova
Clinical pharmacy methodology, organization, education and practice in the Czech Republic

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 2
NS 19 Pharmacology competences for antimicrobial stewardship

Chair: Romaldas Maciulaitis, Kristina Nadrah

16:00 - 16:25 Simona Stankevičiūtė
Clinical pharmacology consultations to improve rational use of antimicrobials: steps towards stewardship program

16:25 - 16:40 Kristina Nadrah
ATB stewardship during covid times

16:40 - 17:05 Romaldas Maciulaitis
Case study in nefrology. How clinical pharmacologist could contribute improving appropriate use of antimicrobials

17:05 - 17:20
ID: 531
Therapeutic drug monitoring of vancomycin - exploring of dosing estimates
Martin Šíma

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 3
S5 Pharmacology of oxidative stress

Chair: Luciano Saso, Jelena Kotur-Stevuljević

Luciano Saso
The importance of modulation of oxidative stress in cancer therapy

Jelena Kotur-Stevuljević
Oxidative stress estimation in pharmacological studies  

 

16:00 - 16:25
ID: 332
The importance of modulation of oxidative stress in cancer therapy
Luciano Saso
16:25 - 16:50
ID: 551
Oxidative stress estimation in pharmacological studies
Jelena Kotur-Stevuljević
16:50 - 17:00
ID: 290
Targeting the master neuronal epigenetic regulator REST as new pharmacological strategy for intervention in Amyotrophic Lateral Sclerosis.
Natascia Guida
17:00 - 17:10
ID: 413
Effects of lifelong omega-3 deficient diet in β amyloid-treated rats: role of redox system
Maria Bove
17:10 - 17:20
ID: 494
Edaravone attenuates disease severity of experimental auto-immune encephalomyelitis and increases gene expression of Nrf2 and HO-1
Hatice Kübra Öztürk

Wednesday, December 08, 2021 16:00 – 17:30

Virtual Hall 4
Recent advances in cannabinoid pharmacology: From Bench to Bedside

Chair: Mark J. Rosenfeld, Mark S. Kindy

Mark Rosenfeld
Cannabidiol (CBD) as Human Medicine – Phase 2 Trials for US Food and Drug Administration (FDA) Approval

Mark S. Kindy
Therapeutic approaches of Cannabinoids in Neurological and Neurodegenerative Disorders

Pavel Gershkovich
Improving the Intestinal Absorption, Efficiency and Selectivity of Cannabidiol (CBD): Importance to the Treatment of Disease States

Wednesday, December 08, 2021 17:50 – 18:20

Virtual Hall 1
Closing Ceremony

Chair: Mojca Kržan